Coenzyme-A and its role in Anti-Aging

by Nickolaos D. Skouras, PhD.

Based upon the genetically determined life span of humans, a normal person has the potential for living a healthy life for over 100 years. As life proceeds, the actual rate at which aging progresses depends upon: (1) the ratio of damage to repair of the body's tissues, cells and molecules, and (2) the progressive loss of body functions. Aging accelerates as time passes. There is evidence that sensory mechanisms (time clocks) in the testes, ovaries, pituitary, and hypothalamus measure accumulated damage and begin to decrease their effective function when such damage reaches a critical level.

Damage to DNA and deterioration of the immune system are both recognized as major causes of aging or premature death. The diseases of age that usually cause disability or death such as arthritis, multiple sclerosis, Parkinson's, Alzheimer's, adult on-set diabetes, cancer, artherosclerosis, etc. are usually prevented or alleviated by a well-functioning immune system and healthy DNA. Coenzyme-A supports critical functions of the immune system and facilitates the repair of RNA and DNA.

Aside from defective genes, or bacterial and viral diseases, the inability of the body to slow or partially reverse the deadly processes of aging can stem from nutritional deficiencies. Unfortunately, it is sometimes difficult to detect a dietary deficiency; however, the effect of most dietary deficiencies is cumulative and the effect of some may be irreversible (and perhaps fatal).

It is advantageous to take essential vitamins and certain nutrients as dietary supplements otherwise, the body must expend raw materials and scarce resources such as enzymes and coenzymes to manufacture the necessary nutrients. Further, as the body ages, its ability to efficiently manufacture and utilize the quantity of nutrients required to maintain good health progressively decreases.

Coenzyme-A is involved in many chemical reactions essential to life: it is essential to processes by which our cells get energy. Coenzyme-A also takes part in the processes by which our cells make fatty acids. Some fatty acids, such as the phospholipids, are essential constituents of cell walls; fats are also involved in the synthesis of other substances, such as parts of the hemoglobin molecule and various amino acids.

For longevity purposes, possibly the two most interesting roles of Coenzyme-A are in the detoxification of toxic substances and the synthesis of cholesterol and steroid hormones made from cholesterol. Coenzyme-A is involved in a very important type of reaction, which occurs in the liver, called acetylation, by which our bodies dispose of many different kinds of toxic substances. The highest content of Coenzyme-A is in the liver, the next highest concentration is in the adrenal glands. The adrenals make corticosterone, a steroid hormone very important in helping our bodies respond to stress of many kinds.

Clinical studies show that Coenzyme-A plays a major role in the body's ability to cope with stress and strengthen the immune system. Stress contributes to the three leading causes of death: cancer, heart attack, and stroke. Studies also show that stress deteriorates the immune system. A healthy immune system is vital for defense against infections, diseases, premature death, and the effects of aging. In combating stress, the body secretes hormones known as glucocorticoids from the adrenal glands as a means to adapt to stress, this is commonly known as the fight-or-flight reaction. These hormones are derivatives of cholesterol and an increased demand for them will draw on the available Coenzyme-A. Lipid (fat) metabolism and energy production may therefore be compromised, rendering the body more prone to depleted energy, weight gain, acne, chronic fatigue syndrome, cancer, heart attack, stroke and other diseases.

Signs and symptoms of a Coenzyme-A deficiency included: depression, anxiety, loss of appetite, impaired sense of balance, easy irritability, fatigue, frequent respiratory infection, cardiac instability, and abnormal need for sleep. Neurological disorders included: numbness, muscle weakness, cramps, abdominal pain and paresthesia (abnormal sensations such as itching and prickling, tingling extremities, and "burning feet" syndrome). Biochemical changes included: increased insulin sensitivity, lowered blood cholesterol, decreased serum potassium, and failure of adrenocorticotropin (ACTH) to induce eosinopenia.

Coenzyme-A is required for energy production in the tissues, an abundance of adrenal hormones may normally cause energy production to go up; however, if the body has a large store of Coenzyme-A already present, it can increase its energy production, and so withstand stress, even if it lacks the adrenal hormones.

Disturbances in the ability of the adrenals to respond to stress with aging have been clearly found in rats (Riegle, GD, NEUROENDOCRINOLOGY 11(1973) 1-10; Riegle, GD and Hess, GD, NEUROENDOCRINOLOGY 9(1972) 175-187).

A long series of measurements over many years has shown decreases with aging in the ability of people to adapt to various physiological stresses such as cold, exercise, or consumption of sugar. Some but not all of these depend on the adrenals, so Coenzyme-A may increase lifespans by providing a substitute for the action of the adrenals and by reducing the damaging effects of stress.

What is special about Coenzyme-A Technologies' products?

Coenzyme-A Technologies Inc. is the world's first developer of effective Coenzyme-A and Acetyl Coenzyme-A products. Coenzyme-A Technologies has applied new technology to the formulation and manufacture of its "Coenzyme ATM" product, which address nutritional deficiencies that result from the stress of modern day living, chemical imbalances within the body, and the effects of aging. Consider the importance of Coenzyme-A! Why risk a dietary deficiency of Coenzyme-A that could affect the quality or duration of life?