DEFINING THE METABOLIC PROCESSES OF HUMAN CELLULAR AGEING

by Nickolaos D. Skouras, PhD.

Introduction

Based upon our current understanding of the Science of Genetics, we are able to correlate the human ageing process with changes that alter the metabolic functions of human cells. Human ageing appears to be associated with the deterioration of the capabilities of the nucleuses and mitochondria of cells. As deterioration progresses, the nucleuses of affected cells fail to continue replicating healthy cells.

Over time such failures will cause a reduction in the supply of the key hormonal chemical agents being produced by the glands and organs of the body. Such reduction in the supply of these key agents is believed to damage the RNA and DNA in a cell's nucleus. This, in turn reduces the ability of these damaged cells to replicate.

Ultimately this complex cellular deterioration accelerates the body's degenerative and destructive ageing process. As this progresses, the body further reduces the its production of key hormonal chemical agents. This causes a repetitive, accelerating, cycle of cellular deterioration and ageing.

To stop this cycle of cellular deterioration and ageing it is essential that the cells of the body access appropriate levels of key metabolic chemical agents. This enables the genetic material within a cell to function efficiently and enables the cell to properly repair and replicate itself.

"It is further believed that the genetic material of each cell has no way of knowing how old it is, except within the reference to the INTRA-CELLULAR FLUID in which it is immersed in."

We thus can safely hypothesize that if the cell receives necessary nutrients and the INTRA-CELLULAR FLUID is kept energized and youthful, then the genetic material within each cell will continue to function in a normal fashion, without any decrease in efficiency.

In addition to slowing the ageing process, it's even possible to reverse the effects of ageing! To do this it is necessary to maintain the homeostatic health of the cellular surface membrane, which delineates The EXTRA-Cellular Fluids from the INTRA-CELLULAR FLUID.

This cellular surface membrane mediates the flow of the essential metabolic chemical agents between the EXTRA and INTRA-Cellular fluids. This is accomplished at receptor sites upon the surface membrane of each cell.

There are numerous types of receptor cites; these cites regulate a wide variety of transfers of amino acids, hormones, and anti-oxidants between the EXTRA and INTRA Cellular fluids.

Using Ionic cellular communication, the surface membrane of a cell plays an essential role in the process of proliferation, migration, differentiation, and re-differentiation of human structure that totally depends upon cellular communication.

The theory of Ionic cellular communication was first supported by mathematical computations using atomic physics. Then was conclusively proven during the 1970's with the invention of glass electrodes with microscopic tips. This technology measured incredibly infinitesimal electrical currents passing through a single Ion channel. Thus enabling the detection of electrical currents of a trillionth of an ampere in the membrane of a human cell.

We now know that all cells have a complex set of Ion channels. This enables a cell to control the flow of Ions in order to perform specific functions. It also provides a cell with the ability to distinguish and control the flow of negative versus positive charged Ions. These charged Ions travel through the Ion channels carrying the information that directs the performance of essential functions in every cell of the human body.

Each cell's surface membrane plays an essential role in controlling the function of the Ionic channels between the EXTRA and INTRA Cellular fluids. This facilitates the movement of agents such as minerals, which move electrostatically between the EXTRA, and INTRA Cellular fluids.

All the body's connective tissues (such as skin tissue and nerves) consist of living cells embedded in an Extra Cellular Matrix (ECM).

This matrix is composed essentially of: (i) water, (ii) large negative charged sugar molecules called Proteoglycans, (iii) their sub components called Glycosaminoglycans, (iv) fibrous proteins called Collagens, and (v) some other non-collagenous proteins.

Glycosaminoglycans (GAGS) are the most abundant heteropolysaccharides in the body. GAGS molecules are long molecular chains of unbranched polysaccharides made up of repeating disaccharide units, which routinely link to Glycoproteins to give whole Proteoglycan structure and are found in the ECM and on cell surfaces.

Our knowledge of the composition and functions of the ECM enable us to discover methods of creating and maintaining a healthy environment within the ECM.

The INTRA Cellular Matrix (ICM) comprises the inner structure of every cell of the body. The ICM includes the cell's nucleus and mitochondria; these are the energy producing elements within each cell.

A cell's nucleus is where most of the genetic functions occur, including that of the ageing process. Accordingly, providing the proper nourishment to a cell's nucleus and mitochondria is an essential aspect of any anti-ageing nutritional therapy.

Eating essential raw organic material foods in a daily diet will provide our body with essential nutrients such as plant enzymes, minerals, vitamins, amino acids and antioxidants.

The cells of our body can also benefit from additional sources of nutrition. We can add supplements to our daily diet that embody advanced nutraceutical technology. Biologically active oral metabolic enzymes, such as
Coenzyme-ATM and the biologically active substrates of RNA and DNA precursors, such as GLYCOMATRIXTM that can vitalize, and continuously rejuvenate the essential components of the body's cells. Such healthy cells would not sense the Environmental changes which they are genetically programmed to associate with the ageing process.

Further, the cells of the Extra Cellular Matrix would benefit from the daily use of topical applications of the latest skin regenerating technological developments embodied in SKIN MATRIXTMproducts.

The SKIN MATRIXTM cosmeceuticals contain all of the essential biologically active components necessary to fully regenerate, and maintain the health of the EXTRA Cellular fluids

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We thus can theoretically hypothesize that by providing the body's cells with an appropriate environment, the cells can actually be deceived into believing that no age related metabolic changes are occurring at a rate that would impede the normal functioning of the cells. There should be no failure to replicate healthy cells and damage to RNA and DNA should be minimal.