Skin Matrix EssenceTM is a newly developed proprietary formula for the
treatment of aging or environmentally damaged human skin.
Upon application, its natural ingredients rejuvenate the texture, and
beautify the appearance of such skin. It easy to use; and continued
use will better preserve the health and beauty of treated skin through
the advancing years.
Recently published scientific studies (that employed a well established
in vitro model of the cellular aging process) report on the effectiveness
of using certain natural ingredients (the Components). When in skin
applications such Components have prevented either completely, or
partially, a variety of the aging related changes in both the
appearance and function of human skin cells.
These Components are incorporated in the Skin Matrix Essence'sTM
proprietary formula (the Formula). Each of these Components is a
natural ingredient with its own functional properties,
which all have been well clinically documented. These components do
extend the cell normal cellular life span, while further enhancing
the ability of these cells to normally divide, and multiply.
Based upon the selection of Components employed and the supporting
scientific publications we believe that Skin Matrix Essence to be
free of all harmful materials. We have scrupulously avoided the use
of a variety of synthetic chemical agents, and preservatives that have
been well incorporated in most of the skin-care products that claim
to revitalize aging skin, found in todays market. The combination of
effectiveness in maintaining normal cell function, appearance and
safety for topical use could make Skin Matrix EssenceTM the lifetime
formula of choice for rebuilding and preserving healthy and attractive skin.
Skin Matrix EssenceTM includes a combination of highly potent energy
promoting and rejuvenating growth factors. There are a variety of
natural plant derived extracts, and mechanisms provided as natural
antioxidants, anti-inflammatory agents, anti-microbial agents,
anti-fungal agents, and lipid-peroxidation inhibitory protective properties.
Also, there is stabilized Orthrosilicic-acid, Aldose, Pentose
sugars, Monosaccharides, Disaccharideâ€™s, Polysaccharides.
In addition, a very unique substance that promotes cellular
regeneration, a €śPolysulfated Glycosaminogly can not only
promotes energy but also enhances healthy cell division and ensures
orderly growth, and development of future healthy skin cells.
Also included are the most effective, naturally occurring, and
biologically active cellular activating components: the GLYCO-MATRIXTM
with Nucleic acids, and DNA precursors.
Certain growth factors are associated with the Extra Cellular Matrix,
which plays a central role in the control of cell proliferation,
differentiation and migration by mediating cell adhesion and
communication. The major components of the Extra Cellular Matrix
include a variety of cell adhesion proteins, fibronectin, vitronectin,
thrombosponding and laminin. Also included are the structural
components: Collagen, Elastin and the Proteoglycans, including
Serglycin, Proteoglycans 1 and 2, Versican, Decotin, and possibly the
other GAG associated proteins that have not as yet been identified.
The Extra Cellular Matrix is present to some degree in all living
tissues, even blood, where plasma might be considered the matrix, but
is a functional determinant in connective tissues. The biologically
active properties in Skin Matrix EssenceTM have been shown to prevent
the senescence (aging), while actually protecting and preserving
cellular membranes from a variety of destructive mechanisms. Such
destructive mechanisms being: non-enzymatic glycosylation and lipid
peroxidation, extreme environmental conditions including total dehydration,
cellular DNA scission, TPA induced inflammation, solar and ionizing
(as in gamma-pyrone derivative) irradiation.
More importantly,Skin Matrix EssenceTM has been shown capable of
delaying or preventing a host of age and environmentally related
changes of human skin fibroblasts grown in laboratory culture.
Fibroblasts are believed to be at the center of age related changes
in the skin. These cells produce collagen and elastin; the two
proteins most clearly tied to the development of wrinkles, sagging
and laxity of the skin. Fibroblasts have been shown to decrease in
number and vitality as the skin ages not only in vitro, but also in
vivo. The number of fibroblasts decreases by at least 50% between
birth and the age of 80 years. The older fibroblasts appear shrunken
and narrow with diminished cytoplasms.
Skin Matrix EssenceTMEffect's on cytological manifestations in vitro aging properties.
|Characteristic||Untreated ||Skin Matrix EssenceTM
|Multinucleate Cells ||None||Present||None||None
|Cellular Debris ||Minimal||Significant||Minimal||Minimal|
|Actin Filaments ||Diffuse||Highly Polymerized ||Diffuse||Less Polymerized|
When propagated in the laboratory, normal human skin cells divide a
predictable number of times and then die. Initially, these cells
proliferate rapidly, then division rates slow. Finally the cells cease
replicating. Cells in late passage are considered €śold cells and have been frequently used in comparative studies with young or early passage cells. A variety of alterations in cell morphology and other cell characteristics occur as the cells progress from young, vigorous cells to old, drying ones.
As has been previously shown in pioneering skin-aging studies,
Hayflick has proposed that the reduction in the potential of human
cultured fibroblasts to divide is a manifestation of the aging process
at the cellular level.
In recently published studies the active proprietary ingredients in
Skin Matrix EssenceTM substantially delayed or prevented a range of
cellular changes associated with in vitro aging of human skin cells,
including alterations in cellular membrane. Refer to Table 1 for
information regarding morphology, growth rate, size, cytoskeletal
organization, macromolecular synthetic activity and accumulation of
liposfuscin aging pigments.
One of the hallmarks of aging tissues is the accumulation of a
variety of lipid-derived pigments called lipofuscins, the so-called
€śwear-and-tear€ť pigment. Lipofuscin interferes with normal cellular
functions, perhaps it even promotes cell death in age associated
pathologies. Old cells treated with the active proprietary ingredients
in Skin Matrix EssenceTM appeared to be similar under the microscope
to young cells; whereas, untreated old cells displayed marked
morphological changes typical of cellular senescence.
Unlike a variety of previously tested agents that can alter certain
features of cellular aging in vitro, the active proprietary
ingredients in Skin Matrix EssenceTM did not in these studies alter
the maximum in vitro life span of human skin cells or their ability to
multiply in culture. Thus the active proprietary ingredients in Skin-Matrix Essence were devoid of such activities associated with
cellular immortalization, mutations, malignant transformation and
finally carcinogenesis. This initial in vitro scientific data suggests
that Skin Matrix EssenceTM biologically possess a combination of
effectiveness and safety in treating aging skin unmatched by any other
revitalizing skin treatments, moisturizers or other skin care programs:
A class of products that wonâ€™t cure (or prevent) wrinkles are the
moisturizing creams and lotions. The beneficial effect of such
cosmetics lasts no longer than several hours beyond their application
and removal. Moisturizers improve the skinâ€™s appearance by hydrating
(temporarily restoring and maintaining water) in the surface of the
Unfortunately in the Stratum Corneum barrier, moisturizers have no
effect at all in restoring hydration. Further, damage can be caused
to the epidermis; some cosmetics contain agents that cause low grade
inflammation and give the appearance of decreasing wrinkles through
sub clinical swelling. Moisturizers generally are composed of water,
oil and humectants. Humectants help the skin retain moisture, thereby
making it more pliable and soft.
Common humectants include glycerin, propylene glycol, pyrrolidone
malic acid, sodium lactate, urea and certain natural lipid mixtures.
More exotic humectants include certain proteins, gelatin, hyaluronic
acid, vitamins and some natural ingredients. In general humectants,
act by penetrating into the stratum corneum and increasing the amount
of moisture that is held in close association with the layer.
Dry skin is characterized by the lack of moisture in the Stratum
Corneum. Moisture originates in the lower skin and moves up through
the Stratum Corneum, where it hydrates the cells and then evaporates
into the atmosphere. The moisture content in the Stratum Corneum
itself is dependent both on naturally occurring lipids and on
intracellular water-soluble substances called natural moisturizing
factors. In aging skin, natural moisturizing factors are only
present in low amounts, and the water-binding capacity is reduced to
about 75% of normal. Moreover, the sebaceous glands produce fewer
lipids to replenish the natural supply and wrinkles compound the
problem by creating more surface area from which water can evaporate.
Published clinical documentation clearly shows that a certain
proprietary ingredient in the Skin Matrix EssenceTM has the ability
to dramatically increase cellular hydration. It also acts as a
stabilizer of cellular structures under extreme environmental
conditions, while further protecting biological membranes, proteins
and enzymes under conditions of elevated temperatures, and even total
dehydration and or freezing temperatures.
While humectants temporally increase the Hydration State of the
Stratum Corneum, they can actually eventually increase the skinâ€™s
water loss by attracting water to the skin surface. This can lead
to a perception of skin tightness or dryness. Therefore, moisturizers
also contain a class of substances, called occlusives, which coat
the skin with an oil substance.
Occlusives include substances like petrolatum, lanolin alcohols,
jojoba oil, cocoa butter, paraffin, cholesterol, heavy lipid mixtures,
olive oil and heavy mineral oil. Moisturizers also contain emollients
and lubricants that provide skin care products with the appropriate
tactile feel and rub-in properties. These lotions smooth the
roughened surface of the Stratum Corneum by filling the spaces between
dry skin cells with oil droplets. Emollients can include a host of
ingredients from silicone oils to cetyl alcohols, cholesterol, mineral
oil, silicone oils, vitamin E, some waxy esters and certain quaternary
Finally collagen and elastin have been added to a number of skin
lotions, and it has been implied that they replace the old, worn out
collagen or elastin in the skin, thus eliminating wrinkles. However,
these extracts of protein are much too large to penetrate the Stratum
Corneum. They merely dry to a protein film that fills in the
irregularities of the skin surface and makes it appear smoother.
Protein films shrink slightly upon drying, thereby stretching out some
of the fine wrinkles and surface irregularities for a short time.
But this is purely a temporary, cosmetic change. Further Liposomes
which have been marketed by the cosmetics industry since the-mid
1980â€™s, have no permanent effect on the skin.
Liposomes do not thoroughly cross through the Stratum Corneum barrier,
as it has been well demonstrated by confocal laser scanning microscopy
(an advanced technique for evaluating the skin permeability barrier
and the assessment of metabolic activity). Liposomes merely coat the
skin surface, causing humectant agents to remain on the skin longer,
thus giving a false sense of improvement.
In closing, Skin Matrix EssenceTM is the first and only organically
active serum with all the biological functions that one should ever
require in their pursuit for a natural skin renewal system,
(while actually reinstating the skin's "HOMEOSTASIS" immune system)
to regenerate and preserve healthy and attractive skin at any age.
These statements have not been evaluated
by the U.S. Food & Drug Administration (FDA).
The products discussed are not intended to diagnose, treat, cure, or prevent
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